Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling

Research output: Contribution to journalJournal articleResearchpeer-review

The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip(R) technology to obtain a more complete description of pineal cell biology. The effort revealed that 604 genes (1,268 probe sets) with Entrez Gene identifiers are differentially expressed greater than 2-fold between midnight and mid-day (false discovery rate
Original languageEnglish
JournalJournal of Biological Chemistry
Issue number12
Pages (from-to)7606-22
Number of pages17
Publication statusPublished - 2009

    Research areas

  • Animals, Circadian Rhythm, Cyclic AMP, Gene Expression Profiling, Gene Expression Regulation, Norepinephrine, Oligonucleotide Array Sequence Analysis, Organ Specificity, Pineal Gland, Rats, Rats, Sprague-Dawley, Retina

ID: 18316349