2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans
Research output: Contribution to journal › Journal article › Research › peer-review
Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.
Original language | English |
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Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 96 |
Issue number | 9 |
Pages (from-to) | E1409-17 |
ISSN | 0021-972X |
DOIs | |
Publication status | Published - 2011 |
- Adult, Blood Glucose, Cyclic AMP, Enteroendocrine Cells, Glucagon-Like Peptide 1, Glycerides, Humans, Male, Oleic Acids, Receptors, G-Protein-Coupled
- Former Faculty of Pharmaceutical Sciences
Research areas
ID: 36082144