Monomethyl branched-chain fatty acids: Health effects and biological mechanisms
Research output: Contribution to journal › Review › Research › peer-review
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Monomethyl branched-chain fatty acids: Health effects and biological mechanisms. / Gozdzik, Paulina; Magkos, Faidon; Sledzinski, Tomasz; Mika, Adriana.
In: Progress in Lipid Research, Vol. 90, 101226, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Monomethyl branched-chain fatty acids: Health effects and biological mechanisms
AU - Gozdzik, Paulina
AU - Magkos, Faidon
AU - Sledzinski, Tomasz
AU - Mika, Adriana
N1 - Copyright © 2023. Published by Elsevier Ltd.
PY - 2023
Y1 - 2023
N2 - Branched-chain fatty acids (BCFA) are a group of lipids that are widely present in various organisms; they take part in numerous biochemical processes and affect multiple signaling pathways. However, BCFA are not well explored in terms of their effects on human health. Recently, they have been gaining interest, especially in relation to various human diseases. This review describes the occurrence of BCFA, their dietary sources, their potential health effects, and the current state of knowledge concerning their mechanism(s) of action. Many studies have been conducted so far in cellular and animal models, which reveal potent anti-cancer, lipid lowering, anti-inflammatory and neuroprotective actions. Research in humans is scarce. Therefore, further studies on animals and humans should be performed to confirm and expand these findings, and improve our understanding of the potential relevance of BCFA to human health and disease.
AB - Branched-chain fatty acids (BCFA) are a group of lipids that are widely present in various organisms; they take part in numerous biochemical processes and affect multiple signaling pathways. However, BCFA are not well explored in terms of their effects on human health. Recently, they have been gaining interest, especially in relation to various human diseases. This review describes the occurrence of BCFA, their dietary sources, their potential health effects, and the current state of knowledge concerning their mechanism(s) of action. Many studies have been conducted so far in cellular and animal models, which reveal potent anti-cancer, lipid lowering, anti-inflammatory and neuroprotective actions. Research in humans is scarce. Therefore, further studies on animals and humans should be performed to confirm and expand these findings, and improve our understanding of the potential relevance of BCFA to human health and disease.
KW - Faculty of Science
KW - Branched-chain fatty acids
KW - Nutrition
KW - Anti-cancer properties
KW - Lipid metabolism
KW - Inflammation
U2 - 10.1016/j.plipres.2023.101226
DO - 10.1016/j.plipres.2023.101226
M3 - Review
C2 - 37094753
VL - 90
JO - Progress in Lipid Research
JF - Progress in Lipid Research
SN - 0163-7827
M1 - 101226
ER -
ID: 345057794