The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies
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The relationship between genetic risk variants with brain structure and function in bipolar disorder : A systematic review of genetic-neuroimaging studies. / Pereira, Licia P; Köhler, Cristiano A; de Sousa, Rafael T; Solmi, Marco; de Freitas, Bárbara P; Fornaro, Michele; Machado-Vieira, Rodrigo; Miskowiak, Kamilla W; Vieta, Eduard; Veronese, Nicola; Stubbs, Brendon; Carvalho, André F.
In: Neuroscience & Biobehavioral Reviews, Vol. 79, 08.2017, p. 87-109.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The relationship between genetic risk variants with brain structure and function in bipolar disorder
T2 - A systematic review of genetic-neuroimaging studies
AU - Pereira, Licia P
AU - Köhler, Cristiano A
AU - de Sousa, Rafael T
AU - Solmi, Marco
AU - de Freitas, Bárbara P
AU - Fornaro, Michele
AU - Machado-Vieira, Rodrigo
AU - Miskowiak, Kamilla W
AU - Vieta, Eduard
AU - Veronese, Nicola
AU - Stubbs, Brendon
AU - Carvalho, André F
N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.
PY - 2017/8
Y1 - 2017/8
N2 - Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.
AB - Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.
KW - Faculty of Social Sciences
KW - Bipolar disorder
KW - Genetic polymorphisms
KW - Neuroimaging
KW - Magnetic resonance imaging
KW - Functional MRI
KW - Diffusion tensor imagingvoxel based morphometry
U2 - 10.1016/j.neubiorev.2017.05.002
DO - 10.1016/j.neubiorev.2017.05.002
M3 - Review
C2 - 28479278
VL - 79
SP - 87
EP - 109
JO - Neuroscience & Biobehavioral Reviews
JF - Neuroscience & Biobehavioral Reviews
SN - 0149-7634
ER -
ID: 184209182