The increasing global interconnectivity influencing land system change brings with it new challenges for land-system science. We evaluate whether recent land-system science (LSS) research into telecoupling provides a basis to set normative goals or priorities for addressing sustainability in coupled human-natural systems. We summarize the challenges for sustainability in an increasingly telecoupled world, particularly the coordination of multisited, multiscalar networks of public and private sector actors. Transnational flows of capital, commodities, energy, people, and waste often span multiple territorial jurisdictions. Thus, effective governance of such systems requires attention to collective decision-making and negotiation among governments, firms, land users, consumers, financial actors, and others.