Nesfatin-1 in human milk and its association with infant anthropometry
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Nesfatin-1 in human milk and its association with infant anthropometry. / Honoré, Karina Dyrvig; Bruun, Signe; Jacobsen, Lotte Neergaard; Domellöf, Magnus; Michaelsen, Kim F.; Husby, Steffen; Zachariassen, Gitte.
In: Nutrients, Vol. 15, No. 1, 176, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Nesfatin-1 in human milk and its association with infant anthropometry
AU - Honoré, Karina Dyrvig
AU - Bruun, Signe
AU - Jacobsen, Lotte Neergaard
AU - Domellöf, Magnus
AU - Michaelsen, Kim F.
AU - Husby, Steffen
AU - Zachariassen, Gitte
N1 - CURIS 2023 NEXS 012
PY - 2023
Y1 - 2023
N2 - Breastfed infants have different growth patterns to formula-fed infants and are less likely to develop obesity later in life. Nesfatin-1 is an anorexigenic adipokine that was discovered in human milk more than a decade ago, and its role in infant appetite regulation is not clear. Our aim was to describe nesfatin-1 levels in human milk collected 3-4 months postpartum, associations with infant anthropometry, and factors (maternal pre-pregnancy body mass index (mBMI), high weight gain during pregnancy, milk fat, and energy content) possibly influencing nesfatin-1 levels. We hypothesized that nesfatin-1 levels in mother's milk would differ for infants that were large (high weight-for-age Z-score (WAZ)) or small (low WAZ) at the time of milk sample collection. We used enzyme-linked immunosorbent assay to detect the nesfatin-1 concentration in milk samples from mothers to high WAZ (n = 50) and low WAZ (n = 50) infants. We investigated associations between nesfatin-1 levels and infant anthropometry at 3-4 months of age and growth since birth, using linear regression adjusted for mBMI, birth weight, infant sex, and exclusivity of breastfeeding. We found no difference in nesfatin-1 levels between the two groups and no association with infant anthropometry, even after adjusting for potential confounders. However, high nesfatin-1 levels were correlated with low mBMI. Future research should investigate serum nesfatin-1 level in both mothers, infants and associations with growth in breastfed children.
AB - Breastfed infants have different growth patterns to formula-fed infants and are less likely to develop obesity later in life. Nesfatin-1 is an anorexigenic adipokine that was discovered in human milk more than a decade ago, and its role in infant appetite regulation is not clear. Our aim was to describe nesfatin-1 levels in human milk collected 3-4 months postpartum, associations with infant anthropometry, and factors (maternal pre-pregnancy body mass index (mBMI), high weight gain during pregnancy, milk fat, and energy content) possibly influencing nesfatin-1 levels. We hypothesized that nesfatin-1 levels in mother's milk would differ for infants that were large (high weight-for-age Z-score (WAZ)) or small (low WAZ) at the time of milk sample collection. We used enzyme-linked immunosorbent assay to detect the nesfatin-1 concentration in milk samples from mothers to high WAZ (n = 50) and low WAZ (n = 50) infants. We investigated associations between nesfatin-1 levels and infant anthropometry at 3-4 months of age and growth since birth, using linear regression adjusted for mBMI, birth weight, infant sex, and exclusivity of breastfeeding. We found no difference in nesfatin-1 levels between the two groups and no association with infant anthropometry, even after adjusting for potential confounders. However, high nesfatin-1 levels were correlated with low mBMI. Future research should investigate serum nesfatin-1 level in both mothers, infants and associations with growth in breastfed children.
KW - Faculty of Science
KW - Human milk components
KW - Nesfatin-1
KW - Appetite regulation
KW - Infant anthropometry
KW - Obesity
U2 - 10.3390/nu15010176
DO - 10.3390/nu15010176
M3 - Journal article
C2 - 36615833
VL - 15
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 1
M1 - 176
ER -
ID: 332048634