In recent years the search for more sustainable products has motivated many scientists to investigate the technical feasibility of different lignocellulose materials for use in various materials. Among them we can detach the sisal fiber bundles that are already used by different segments of the plastic industry. This lignocellulose material has gained prominence due to several mechanical and economic characteristics. Thus, the aim of this study was to evaluate the potential use of sisal bundles in association with eucalyptus particles for the production of MDP panels. Panels were prepared with the substitution on eucalyptus wood for sisal bundles in the panels’ core in doses of 0, 5, 10, 15, 20 and 25%. The MDP panels were produced with face/core 40/60 (base dry mass of the particles), urea-formaldehyde adhesive, nominal density of 0,70 g.cm-3 and pressing cycle of 8 minutes, 3,92 MPa pressure and temperature of 160°C. The results were not satisfactory because the inclusion of the sisal bundles resulted in worsening the analyzed properties.