TY - JOUR

T1 - Intentional weight loss improved performance in obese ischaemic heart patients: A two centre intervention trial

AU - Geiker, Nina Rica Wium

AU - Myint, Khin Swe

AU - Heck, Patrick

AU - Dhatariya, Ketan

AU - Larsen, Sisse Marie Hørup

AU - Andersen, Malene Rohr

AU - Stender, Steen

AU - Torp-Pedersen, Christian

AU - Finer, Nick

AU - Astrup, Arne

N1 - CURIS 2014 NEXS 427

PY - 2014

Y1 - 2014

N2 - Aims: The risk of heart failure (HF) increases with BMI, but paradoxically obesity has been associated with reduced mortality in patients with HF. The effect of intentional or therapeutic weight loss on HF is not well known. We examined the effect of weight loss induced by low energy diet (LED) on physical performance and cardiovascular risk factors in obese patients with moderate-to-severe HF and/or ischaemic heart disease (IHD).Methods and Results: Results from two weight loss interventions at two centres, one in Denmark (DK - 12 week intervention in 21 subjects (14 LED, 7 controls)) and one in UK, (16 week intervention in 11 subjects (all LED, no controls) werecombined for a total of 32 subjects with HF or IHD and median BMI 36.2 kg/m2 (range 30-50). Weight loss was initiated with LED (800 kcal/day) followed by energy restricted and protein-rich diet (1200 kcal/day). Physical performance wasmeasured by six-minute walk test (DK) and maximum oxygen uptake (UK). The effect of treatment was analysed using linear mixed model. Weight loss in the intervention group: 13.9kg ± 6.5 and 1.21kg ± 1.8 in controls (P=0.000). Physical performance (the primary outcome) was improved by 17.8% ± 23.1 in the intervention group versus -22.1% ± 25.6 in the control group (P=0.000). Treatment also improved triglycerides (P=0.000), very low lipoprotein (P=0.001) and C-reactive protein (P=0.010).Conclusion: Weight loss induced by LED in obese patients with moderate-to-severe HF or IHD resulted in clinically significant improvement in physical performance and cardiovascular risk markers.

AB - Aims: The risk of heart failure (HF) increases with BMI, but paradoxically obesity has been associated with reduced mortality in patients with HF. The effect of intentional or therapeutic weight loss on HF is not well known. We examined the effect of weight loss induced by low energy diet (LED) on physical performance and cardiovascular risk factors in obese patients with moderate-to-severe HF and/or ischaemic heart disease (IHD).Methods and Results: Results from two weight loss interventions at two centres, one in Denmark (DK - 12 week intervention in 21 subjects (14 LED, 7 controls)) and one in UK, (16 week intervention in 11 subjects (all LED, no controls) werecombined for a total of 32 subjects with HF or IHD and median BMI 36.2 kg/m2 (range 30-50). Weight loss was initiated with LED (800 kcal/day) followed by energy restricted and protein-rich diet (1200 kcal/day). Physical performance wasmeasured by six-minute walk test (DK) and maximum oxygen uptake (UK). The effect of treatment was analysed using linear mixed model. Weight loss in the intervention group: 13.9kg ± 6.5 and 1.21kg ± 1.8 in controls (P=0.000). Physical performance (the primary outcome) was improved by 17.8% ± 23.1 in the intervention group versus -22.1% ± 25.6 in the control group (P=0.000). Treatment also improved triglycerides (P=0.000), very low lipoprotein (P=0.001) and C-reactive protein (P=0.010).Conclusion: Weight loss induced by LED in obese patients with moderate-to-severe HF or IHD resulted in clinically significant improvement in physical performance and cardiovascular risk markers.

KW - Faculty of Science

KW - Heart failure

KW - Ischaemic heart disease

KW - Weight loss

KW - Maximum oxygen uptake

KW - Six Minutes Walk Test

M3 - Journal article

VL - 1

JO - Jacobs Journal of Food and Nutrition

JF - Jacobs Journal of Food and Nutrition

SN - 2376-9211

IS - 1

M1 - 003

ER -