Transforming growth factor-β activation in cell-free extracellular matrix preparations: Commentary
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Transforming growth factor-β activation in cell-free extracellular matrix preparations : Commentary. / Couchman, John R.
I: Folia Histochemica et Cytobiologica, Bind 57, Nr. 4, 2019, s. 157-158.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Transforming growth factor-β activation in cell-free extracellular matrix preparations
T2 - Commentary
AU - Couchman, John R
PY - 2019
Y1 - 2019
N2 - Transforming growth factor-β (TGF-β) is an important regulator of many cellular and immunological functions. It is often deposited in extracellular matrices in a latent form. This commentary is to draw attention to the likelihood that preparing cell-free matrices from tissue cultures by high pH buffers, such as ammonium hydroxide, can activate the TGF-β. Therefore, cells subsequently seeded onto such matrices may respond to the presence of active TGF-β in addition to interactions with macromolecular extracellular matrix components.
AB - Transforming growth factor-β (TGF-β) is an important regulator of many cellular and immunological functions. It is often deposited in extracellular matrices in a latent form. This commentary is to draw attention to the likelihood that preparing cell-free matrices from tissue cultures by high pH buffers, such as ammonium hydroxide, can activate the TGF-β. Therefore, cells subsequently seeded onto such matrices may respond to the presence of active TGF-β in addition to interactions with macromolecular extracellular matrix components.
KW - Faculty of Health and Medical Sciences
U2 - 10.5603/FHC.a2019.0017
DO - 10.5603/FHC.a2019.0017
M3 - Journal article
C2 - 31743418
VL - 57
SP - 157
EP - 158
JO - Folia Histochemica et Cytobiologica
JF - Folia Histochemica et Cytobiologica
SN - 0239-8508
IS - 4
ER -
ID: 231600560