Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Young mink kits (n = 8)were vaccinated withDNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodieswere induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN- producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.
Originalsprog | Engelsk |
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Tidsskrift | Vaccine |
Vol/bind | 27 |
Udgave nummer | 38 |
Sider (fra-til) | 5178–5183 |
Antal sider | 6 |
ISSN | 0264-410X |
DOI | |
Status | Udgivet - 2009 |
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ID: 13458253