Over the past 25 years, the study of driving forces of landscape change has developed into a central theme in land change science by contributing to theory development, promoting the analysis of causation of change and gaining insights into how landscape development could be steered into a societally more desirable direction. Based on this progress, we designate important research avenues, reviewing critical challenges forming the base for advancing the study of driving forces of landscape change and addressing the question on how the study of driving forces can contribute to system transformative research. For each of the research avenues, we describe the current dominant approach and provide some specific ways of advancing both the conceptualization and the research methods. Together, advancing on these research avenues will promote a more social-ecological systems perspective to the study of driving forces of landscape change.