The COVID-19 pandemic led to a sharp economic contraction. A comprehensive understanding of the relationship between the spatial composition of production factor (SCPF) and socioeconomic recovery is still missing. Here, we applied the contrasting status of nitrogen dioxide (NO₂) concentrations in cities in central and eastern China as natural laboratories. From the perspective of the spatial composition of land (SCL) and the dependence on the inflow population (DIP), four quantifiable indicators (resilience, impact, sensitivity, recovery speed) were used to analyze the adaptability of SCPF to the epidemic lockdown. The results indicate that appropriate SCPF is a prerequisite for a complete “land-population-industry” nexus. The built-up area proportion is below 74.38%, with higher adaptability to epidemic shocks. The range of rural built-up proportion conducive to economic recovery is 10.18%-15.18%. The proportions of various land types inside the city's defense unit should also be constrained. Similarly, DIP is advocated to be maintained below 17.5%. For urban-rural fringe areas, the response to epidemic prevention and socioeconomic recovery are rapid. This observation-driven study indicated that COVID-19 is a shocking reminder for policymakers, to improve the socioeconomic recovery ability from the spatial composition of production factor perspective in the post−COVID−19 era.