The highly prolific Murzuq basin in SW Libya was considered devoid of large sand injection system and volcanic activity during the Lower Palaeozoic. This study identified numerous evidences of kilometre-scale sand injections in association with volcanism of Lower Devonian age. The sand injection system is original by its interaction with volcanism and its situation in an epicontinental intracratonic basin. The sand injections form a seal-bypass system between the Ordovician-Cambrian reservoirs and the Lower Devonian sandstones, breaching through the Silurian shale seal (and source rock). The discovery is important to understand the fluid-flow patterns and thermal history of such basin and should be considered during petroleum exploration of similar North African basins.