Moderate alcohol consumption and chronic disease: The case for a long-term trial
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Moderate alcohol consumption and chronic disease: The case for a long-term trial. / Mukamal, Kenneth J; Clowry, Catherine M; Murray, Margaret M; Hendriks, Henk F J; Rimm, Eric B; Sink, Kaycee M; Adebamowo, Clement A; Dragsted, Lars Ove; Lapinski, P Scott; Lazo, Mariana; Krystal, John H.
I: Alcoholism: Clinical and Experimental Research, Bind 40, Nr. 11, 2016, s. 2283-2291.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Moderate alcohol consumption and chronic disease: The case for a long-term trial
AU - Mukamal, Kenneth J
AU - Clowry, Catherine M
AU - Murray, Margaret M
AU - Hendriks, Henk F J
AU - Rimm, Eric B
AU - Sink, Kaycee M
AU - Adebamowo, Clement A
AU - Dragsted, Lars Ove
AU - Lapinski, P Scott
AU - Lazo, Mariana
AU - Krystal, John H
N1 - CURIS 2016 NEXS 301
PY - 2016
Y1 - 2016
N2 - Drinking within recommended limits is highly prevalent in much of the world, and strong epidemiological associations exist between moderate alcohol consumption and risk of several major chronic diseases, including coronary heart disease, diabetes, and breast cancer. In many cases, plausible biological mediators for these associations have been identified in randomized trials, but gold standard evidence that moderate drinking causes or prevents any chronic disease remains elusive and important concerns about available evidence have been raised. Although long-term randomized trials to test the observed associations have been termed impossible, clinical investigators have now successfully completed randomized trials of complex nutritional interventions in a variety of settings, along with trials of alcohol consumption itself of up to 2 years duration. The successful completion of these trials suggests that objections to the execution of a full-scale, long-term clinical trial of moderate drinking on chronic disease are increasingly untenable. We present potential lessons learned for such a trial and discuss key features to maximize its feasibility and value.
AB - Drinking within recommended limits is highly prevalent in much of the world, and strong epidemiological associations exist between moderate alcohol consumption and risk of several major chronic diseases, including coronary heart disease, diabetes, and breast cancer. In many cases, plausible biological mediators for these associations have been identified in randomized trials, but gold standard evidence that moderate drinking causes or prevents any chronic disease remains elusive and important concerns about available evidence have been raised. Although long-term randomized trials to test the observed associations have been termed impossible, clinical investigators have now successfully completed randomized trials of complex nutritional interventions in a variety of settings, along with trials of alcohol consumption itself of up to 2 years duration. The successful completion of these trials suggests that objections to the execution of a full-scale, long-term clinical trial of moderate drinking on chronic disease are increasingly untenable. We present potential lessons learned for such a trial and discuss key features to maximize its feasibility and value.
KW - Faculty of Science
KW - Randomized controlled trial
KW - Feeding studies
U2 - 10.1111/acer.13231
DO - 10.1111/acer.13231
M3 - Review
C2 - 27688006
VL - 40
SP - 2283
EP - 2291
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
SN - 0145-6008
IS - 11
ER -
ID: 167923125