Our PhD research consists in analysing and modelling the vegetation response or sensitivity to climatic stresses with low satellite imagery. In that framework, the selection of optimal calibration sites is very important. These sites should be characterised by a stable and homogenous land cover over large area. Here we analyse the spatial heterogeneity of the aggregation entities (EU-NUTS 2) used by the MARS-FOOD programme for the extraction of regional NDVI-means.