Local application of FFR-rFVIIa reduces thrombus formation at arterial anastomosis in rats
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Thrombosis is still a significant problem in microvascular surgery. The aim of this study was to evaluate the antithrombotic effect of topically applied active site-inhibited recombinant human factor VIIa (FFR-rFVIIa) in a rat model with microvascular thrombosis. Forty-five male rats were allocated to one of three groups: local treatment with vehicle only, local treatment with 0.035 mg of FFR-rFVIIa, or local treatment with 0.35 mg of FFR-rFVIIa. An arteriotomy was made in the right femoral artery. Ten minutes following topical application, a thrombogenic anastomosis was performed. Using a transilluminator, thrombus formation and anastomotic bleeding episodes were observed and registered for 40 min. Local application of FFR-rFVIIa resulted in a 85-90% reduction of thrombus formation in both treated groups compared to the control group, but the reduction was only statistically significant in the group treated with 0.035 mg of FFR-rFVIIa. An increased occurrence and duration of anastomotic bleeding episodes were observed in both FFR-rFVIIa-treated groups.
Originalsprog | Engelsk |
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Tidsskrift | Microsurgery |
Vol/bind | 19 |
Udgave nummer | 8 |
Sider (fra-til) | 369-73 |
Antal sider | 5 |
ISSN | 0738-1085 |
DOI | |
Status | Udgivet - 1999 |
Bibliografisk note
Copyright 1999 Wiley-Liss, Inc.
ID: 243520873