We present petrological data and seven Lu-Hf garnet–amphibole–whole rock ages obtained from a single garnet-hornblende-mica schist sample from the Isua supracrustal belt (West Greenland). Garnets grew during prograde metamorphism toward regional amphibolite-facies peak conditions, and a mylonitic foliation formed during and after garnet growth. Garnet crystals show typical prograde zoning with no visible traces of a relict garnet generation. They do show various degrees of retrogression. While some crystals are perfectly euhedral with only minor chemical alteration along cracks, others are elongated in the foliation and either grew in this shape or were deformed. Six garnet splits were separated from crushed single crystals and one from a crushed bulk sample. Individual three-point garnet–hornblende–whole rock ages scatter between 2.603 ± 0.018 Ga and 2.432 ± 0.059 Ga for single garnets. The garnet split from the bulk sample defines an age of 2.463 ± 0.031 Ga, the data point farthest from the regression line for all data points (2.551 ± 0.074 Ga, mean square of weighted deviates = 25). We interpret these data to indicate partial retrogression of a Neoarchean garnet population not significantly older than the oldest obtained three-point age. Well-preserved garnet zoning, regional peak temperatures well below the closing temperature of the Lu-Hf system, and the small scatter of Lu-Hf ages preclude an interpretation of the observed metamorphism and deformation as being Eoarchean in age.