The application of the SHRIMP U/Pb dating technique to zircon and monazite of different rock types of the Sierras de Córdoba provides an important insight into the metamorphic history of the basement domains. Additional constraints on the Pampean metamorphic episode were gained by Pb/Pb stepwise leaching (PbSL) experiments on two titanite and garnet separates. Results indicate that the metamorphic history recorded by Crd-free gneisses (M2) started in the latest Neoproterozoic/earliest Cambrian (553 and 543 Ma) followed by the M4 metamorphism at ~530 Ma that is documented in the diatexites. Zircon ages of 492 Ma in the San Carlos Massif correlate partly with rather low Th/U ratios (<0.1) suggesting their growth by metamorphic fluids. This age is even younger than the PbSL titanite ages of 506 Ma. It is suggested that the fluid alteration relates to the beginning of the Famatinien metamorphic cycle in the neighbouring Sierra de San Luis and has not affected the titanite ages. The PTt evolution can be correlated with the plate tectonic processes responsible for the formation of the Pampean orogene, i.e., the accretion of the Pampean basement to the Río de La Plata craton (M2) and the later collision of the Western Pampean basement with the Pampean basement.