Uncertainty and change are the hallmarks of contemporary life. Global climate change, ecological regime shifts, and urban transformations catalyze new levels of socio-spatial precarity. Exacerbated by political and economic conditions, accelerating change and un- certainty have disrupted people-place relationships and created anxiety around real and perceived place loss and threat. In this article, we outline the potential of senses of place—both pluralized and politicized—to generate new possibilities for thinking, acting, and designing in response to disruption. Three different case studies demonstrate how senses of place can guide us through disruption. For each case, we examine the nature of the disruption/place change, describe how senses of place are involved in the disruption, and consider the role of landscape architecture in helping communities respond. Together, these cases demonstrate that a deeper understanding of senses of place offers a way to respond to disruptions that enables new beginnings to unfold, facilitates the coproduction of knowledge, and supports socio-spatial justice.